The comparative genomics of T-box genes

673 Comparative Genomics of Angiosperm MADS Box Genes

Vivian F. Irish Yale University, New Haven, CT. MADS box genes encode key transcriptional regulators that have been implicated in the control of various aspects of floral development, primarily through work carried out in Arabidopsis. We have embarked on a series of analyses to examine the extent to which gene duplication, regulatory diversification and differences in protein interactions have ...

Computational Comparative Genomics : Genes , Regulation ,

Green Genes—Comparative Genomics of the Green Branch of Life

As more plant genome sequences become available, researchers are increasingly using comparative genomics to address some of the major questions in plant biology. Such questions include the evolution of photosynthesis and multicellularity, the developmental genetic changes responsible for alterations in body plan, and the origin of important plant innovations such as roots, leaves, and vascular ...

T-box genes in human disorders.

The T-box gene family encodes a large family of transcription factors with more than 20 members identified in humans so far, and homologues in many other organisms. A number of human disorders have been linked to mutations in T-box genes, confirming their medical importance. They include Holt- Oram syndrome/TBX5, Ulnar-Mammary syndrome/TBX3, and more recently DiGeorge syndrome/TBX1, ACTH defici...

T-box genes in vertebrate development.

The myriad developmental roles served by the T-box family of transcription factor genes defy easy categorization. Present in all metazoans, the T-box genes are involved in early embryonic cell fate decisions, regulation of the development of extraembryonic structures, embryonic patterning, and many aspects of organogenesis. They are unusual in displaying dosage sensitivity in most instances. In...